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C57BL/6J DIO
品系货号：380050 ｜ 通用名称：B6 DIO 小鼠
又名：B6 DIO, B6J DIO, Black 6 DIO, DIO Mouse, Diet-induced Obesity
高脂饮食会造成许多疾病，包括肥胖症、代谢性疾病和炎症性疾病。杰克森实验室目前拥有饮食诱导肥胖 (diet-induced obese, DIO) C57BL/6J 模型小鼠资源库，以便在您需要时为您提供所需小鼠。DIO C57BL/6J 小鼠是具有轻度血糖升高以及糖耐量降低的II 型糖尿病前期和肥胖症模型小鼠，可供代谢研究使用。杰克森实验室提供可直接用于研究的饮食诱导肥胖 (DIO) C57BL/6J 雄鼠和对照小鼠，这些小鼠会在 6 周龄时开始饲喂，在 7-25 周龄时售出，满足您特殊的研究需求。若项目需要定制饮食或诱导不同品系，杰克森实验室项目经理可以协助您获得所需小鼠。
重点提示：本品系为Cdh23ahl纯合子，携带年龄相关的听力丧失突变1，其听力在10月龄后开始出现问题并随年龄增加而进展。
品系特点
原始参考文献
当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中提供该品系的品系货号：JAX stock #380050
查阅参考文献 > 当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中提供该品系的品系货号：JAX stock #380050品系详情
用高脂饲料饲喂的 C57BL/6J 小鼠，会出现肥胖症、轻度高血糖症、血脂异常和糖耐量减低（请参见表型数据详情）。
1984 年之前的某一时间，C57BL/6J 小鼠的烟酰胺核苷酸转移酶 (Nnt) 外显子 7-11 发生了自然缺失。这种缺失导致 NNT 蛋白的缺失，与葡萄糖内稳态控制受损和胰岛素分泌减少相关。此突变不存在于 C57BL/6JEi、C57BL/6N、C57BL/6NJ、C57BL/6ByJ、C57BL/10J、C57L/J 或 C58/J 小鼠中 (Toye AA, et al, Diabetologia, 2005)。因为品系 C57BL/6JEi 是在 1976 年从 C57BL/6J 中分离出来的，而Nnt 缺失发生在 1976 年至 1984 年之间。
品系建立
C57BL/6J 近交品系由 CC Little 博士将来自 Abbie Lathrop 女士的储备库中 57 号雌鼠与 52 号雄鼠交配繁育获得。这一交配繁育也产生了 C57L 和 C57BR 品系。
参考文献
精选参考文献
当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中提供该品系的品系货号：JAX stock #380050
2016
Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium.
Fontaine DA , et al.
2008
Genetic background determines metabolic phenotypes in the mouse.
Champy MF , et al.
2005
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Toye AA , et al.
健康报告 屏障设施级别描述 >
育种须知 更多繁育和饲养支持 >
此品系繁育表现良好。
繁育策略
同胞兄弟姐妹交配
销售和使用条款
法务咨询
电话： 001-207-288-6470（美国）
电子邮件： TechTran@jax.org
380050
B6 DIO
肥胖症，代谢性疾病，炎症性疾病
参考文献|
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精选参考文献当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中提供该品系的品系货号：JAX stock #380050
2016Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium.
Fontaine DA , et al.
2008Genetic background determines metabolic phenotypes in the mouse.
Champy MF , et al.
2005A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Toye AA , et al.
2004Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.
Petkov PM , et al.
2002Initial sequencing and comparative analysis of the mouse genome.
Waterston RH , et al.
2001Genetic loci determining bone density in mice with diet-induced atherosclerosis.
Drake TA , et al.
1998Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice.
Black BL , et al.
1995Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes.
Kirk EA , et al.
1995Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse.
Paigen B , et al.
1994Diet-induced obesity and diabetes in C57BL/6J and C57BL/KsJ mice
Surwit RS , et al.
1991Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H.
Ishida BY , et al.
1990Synthetic low and high fat diets for the study of atherosclerosis in the mouse.
Nishina PM , et al.
1985Variation in susceptibility to atherosclerosis among inbred strains of mice.
Paigen B , et al. -
其它参考文献
2016Unstable FoxP3+ T regulatory cells in NZW mice.
Depis F , et al.
2014RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration.
Ishimura R , et al.
2013C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response.
Kumar V , et al.
2011Genetic polymorphisms among C57BL/6 mouse inbred strains.
Zurita E , et al.
2009Genetic differences among C57BL/6 substrains.
Mekada K , et al.
2009Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen.
Zhu W , et al.
2008Oxidative damage-induced inflammation initiates age-related macular degeneration.
Hollyfield JG , et al.
2007Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.
Moy SS , et al.
2006Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice.
Freeman HC , et al.
2004Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
Goren HJ , et al.
2004An efficient SNP system for mouse genome scanning and elucidating strain relationships.
Petkov PM , et al.
2003Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity.
Rossmeisl M , et al.
2003Allergen-induced airway disease is mouse strain dependent.
Whitehead GS , et al.
2003Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Xu H , et al.
2000Genetic regulation of primitive hematopoietic stem cell senescence.
Chen J , et al.
2000Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.
Ewart SL , et al.
2000Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.
Nguyen PV , et al.
2000Genetic heterogeneity of angiogenesis in mice.
Rohan RM , et al.
2000The Dalila effect: C57BL6 mice barber whiskers by plucking.
Sarna JR , et al.
2000Macronutrient diet selection in thirteen mouse strains.
Smith BK , et al.
1999Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice.
Beamer WG , et al.
1998Comparison of acute endotoxin-induced lesions in A/J and C57BL/6J mice.
O'Malley J , et al..
1998Reversal of diet-induced obesity and diabetes in C57BL/6J mice.
Parekh PI , et al.
1998Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.
Roberts JE , et al.
1997Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss.
Parham K , et al.
1996Genetic variability in adult bone density among inbred strains of mice.
Beamer WG , et al.
1996Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss.
Erway LC , et al.
1995Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.
Surwit RS , et al.
1994Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.
Bultman SJ , et al.
1994Alcohol consumption by C57BL/6, BALB/c, and DBA/2 mice in a limited access paradigm.
Le AD , et al.
1994Microphthalmia and associated abnormalities in inbred black mice.
Smith RS , et al.
1994Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.
Vrieling H , et al.
1993Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.
Miller MW , et al.
1993Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.
Nishina PM , et al.
1992Molecular characterization of the mouse agouti locus.
Bultman SJ , et al.
1992Dietary obesity in nine inbred mouse strains.
West DB , et al.
1990Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors.
Jiao S , et al.
1990Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.
Paigen B , et al.
1986Differences in susceptibility of inbred mice to Bacillus anthracis.
Welkos SL , et al.
1982Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.
Schlagel CJ , et al.
外观
被毛颜色
Black
详情
