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B6.129S7-Ldlrtm1Her/J
品系货号：002207 ｜ 通用名称：Ldlr KO 小鼠
此品系Ldlrtm1Her突变纯合小鼠的血清胆固醇水平升高至200-400 mg/dL；如饲喂高脂饲料，其血清胆固醇水平将会非常高 (>2,000 mg/dL)。小鼠血清胆固醇的正常水平为80-100 mg/dL。
品系特点
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同源品系
靶向突变
原始参考文献
当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中注明该品系的品系货号：JAX stock #002207
查阅参考文献 > 当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中注明该品系的品系货号：JAX stock #002207
品系捐赠者 杰克森实验室小鼠资源库 - 杰克森实验室
品系详情
此品系Ldlrtm1Her 突变纯合小鼠的血清胆固醇水平升高至200-400 mg/dL；如饲喂高脂饲料，其血清胆固醇水平将会非常高 (>2,000 mg/dL)。小鼠血清胆固醇的正常水平为80-100 mg/dL。
品系建立
Ldlrtm1Her 突变品系由德克萨斯大学达拉斯西南医学中心霍华德·休斯医学研究所研究实验室的Robert Hammer博士和Joachim Herz博士实验室建立。将新霉素耐药基因片段插入4号外显子后，预计可编码截短的非功能性蛋白，该蛋白不会结合LDL，并且不含跨膜片段。在品系建立过程中，使用了源自129的AB1 ES细胞系。此品系已与 C57BL/6J小鼠回交10代(N10)。
参考文献
精选参考文献
当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中注明该品系的品系货号：JAX stock #002207
1993
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]
Ishibashi S , et al.
健康报告 屏障设施级别描述 >
育种须知 更多繁育和饲养支持 >
此Ldlrtm1Her品系通过纯合同胞兄弟姐妹交配来维持。目前仅可订购纯合小鼠。
繁育策略
纯合雌鼠 X 纯合雄鼠
销售和使用条款
法务咨询
电话： 001-207-288-6470（美国）
电子邮件： TechTran@jax.org
002207
Ldlr KO
代谢疾病、心血管疾病、糖尿病与肥胖症研究
参考文献|
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精选参考文献当使用该小鼠品系发表文献时，请引用原始参考文献，并在材料方法中注明该品系的品系货号：JAX stock #002207
1993Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]
Ishibashi S , et al. -
其它参考文献
2004Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.
Knouff C , et al.
2004Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins.
Lie J , et al.
2004Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions.
Renard CB , et al.
2004Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.
Schiller NK , et al.
2004Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.
Shi W , et al.
2004Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain.
Welch CL , et al.
2003Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.
Binder CJ , et al.
2002Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation.
Kulinski A , et al.
2002LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice.
Schreyer SA , et al.
2002Loss of Lymphotoxin-alpha but Not Tumor Necrosis Factor-alpha Reduces Atherosclerosis in Mice.
Schreyer SA , et al.
2002Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.
van Eck M , et al.
2002Macrophage-specific expression of class A scavenger receptors in LDL receptor(-/-) mice decreases atherosclerosis and changes spleen morphology.
Whitman SC , et al.
2001Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice.
Merkel M , et al.
2001Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.
Tangirala RK , et al.
2001Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model.
Welch CL , et al.
2000Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
Babaev VR , et al.
2000Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.
Huszar D , et al.
2000Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.
Keren P , et al.
2000Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice [see comments]
Schonbeck U , et al.
2000Analysis of low-density lipoprotein catabolism by primary cultures of hepatic cells from normal and low-density lipoprotein receptor knockout mice.
Truong TQ , et al.
1995Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.
Herz J , et al.
1994Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.
Ishibashi S , et al.
1994The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.
Ishibashi S , et al.
