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BALB/cJ
品系货号：000651 ｜ 通用名称：BALBc
又名：C, BALB, BALB/c
BALB/cJ 是常用的近交小鼠品系。其关键特征有，在感染 Theiler 氏鼠脑脊髓炎病毒后易发生脱髓鞘病。BALB/cJ亚系对李斯特菌、所有种属的利什曼原虫和数个种属的锥虫易感，但对实验性变态反应性睾丸炎 (experimental allergic orchitis, EAO) 具有抗性。
品系特点 品系详情 品系建立 参考文献 基因分型和繁育 销售和使用条款
 
 
品系特点
近交系
  
原始参考文献
Info 当使用该小鼠品系发表文献时，请引用原始文献，并在材料方法中提供该品系的品系货号：JAX stock#000651
查阅参考文献 >
  
品系详情
众所周知，BALB/c 小鼠注射矿物油后产生浆细胞瘤，此为单克隆抗体产生的基础。尽管尚未检查所有 BALB/c 亚系的浆细胞瘤诱导情况，但是通过 Andervont (An) 谱系（包括 BALB/cByJ）获得的亚系通常易感，而通过 BALB/cJ 获得的亚系则具有抗性（请参见：Potter M, 1985）。在正常情况下，此品系的乳腺肿瘤发病率较低，但接种经 MMTV+ C3H 小鼠孵育的乳腺肿瘤病毒后，肿瘤数量显著增加，且发病周龄提前。BALB/c 小鼠在生命后期会出现其他癌症，包括网状肿瘤、原发性肺癌和肾肿瘤。在 BALB/cJ 和 BALB/cByJ 亚系中，均观察到由各种外分泌腺的肌上皮细胞引起的罕见自发性肌上皮瘤。研究发现，该品系易感染单核细胞增生李斯特菌，雌鼠感染后至死亡的中位时间为 3 天 (Cheers and McKenzie, 1978)。
White 等人报道了 4 个品系中硫乙醇酸盐培养基诱导的腹膜白细胞募集差异。总白细胞募集的反应由强到弱依次为：C57BL/6J > BALB/c > CD1 > 129X1/SvJ。研究还发现，在反应时间线和受影响最大的细胞类型方面也存在差异。
PLP180-199 免疫 BALB/c 小鼠出现非典型性实验性自身免疫性脑脊髓炎 (experimental autoimmune encephalomyelitis, EAE)，其易感性由感染位置决定。对于脊髓感染，有 60-70% 的小鼠出现病理性病变，而对于大脑和小脑感染，则全部 (100%) 小鼠均出现严重病变。 在部分 BALB/cJ 雌鼠中观察到背腹侧阴道膈，可能导致雌鼠无生育能力。(Cunliffe-Beamer T, Lab Anim Sci, 1976)
BALB/c 小鼠易患营养不良性心脏钙质沉着症（心脏组织矿化）。Steven Taffet 博士实验室的一项研究报告比较了杰克森实验室提供的 BALB/cByJ 和 BALB/cJ 小鼠，BALB/cByJ 小鼠（44/49；5 周龄时为 90%）表现出的钙质沉积发病率和严重程度高于 BALB/cJ（1/6；5 周龄时为 17%）或其他 BALB/c 亚系小鼠 [Glass et al. 2013 Comp Med 63: 29 (PMID:23561935)]。
小鼠通常会出现黄色毛发，尤其是生殖器周围（可能是排尿污渍造成的），并可能伴随局部脱毛，在老年小鼠中该现象更为明显。
品系建立
此品系是 BALB（Bagg 白化小鼠）的亚系，最初的 BALB 品系由 MacDowell 在冷泉港饲养，最后送至德克萨斯州大学的 G.D. Snell。1932 年，Snell 将 F26 代小鼠带到杰克森实验室。1937-1939 年间，Snell 带来的 BALB/c 小鼠被分为三个分支谱系，即 Andervont (BALB/cAn)、Scott (BALB/cSc) 和 Green (BALB/cGn)。1941 年，BALB/cSc 谱系在 F41 代最终变为 BALB/cJ。
参考文献
精选参考文献
当使用该小鼠品系发表文献时，请引用原始文献，并在材料方法中提供该品系的品系货号：JAX stock#000651
2017

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

Timmermans S , et al.

PubMed:28784771

MGI:J:244295

Proc Natl Acad Sci U S A 114(34):9158-9163

2004

Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.

Petkov PM , et al.

PubMed:15081119

MGI:J:89298

Genomics 83(5):902-11

1978

Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.

Cheers C , et al.

PubMed:305895

MGI:J:5965

Infect Immun 19(3):755-62

浏览所有参考文献 >
基因分型和繁育
基因分型 基因分型相关资源>
Allele Symbol GAL Panel
Allele Specific Protocols
Separated PCR
  
Allele Symbol H2<d>-EP
Allele Specific Protocols
End Point Analysis
  
健康报告 屏障设施级别描述 >
育种须知 更多繁育和饲养支持 >
此品系繁育表现良好。
繁育策略
同胞兄弟姐妹交配
销售和使用条款
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000651
BALBc
Inbred Strain
近交系
肿瘤、免疫学、生理学、核医学研究、单克隆抗体制备
参考文献|
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    精选参考文献
    当使用该小鼠品系发表文献时，请引用原始文献，并在材料方法中提供该品系的品系货号：JAX stock#000651
    2017
    Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.
    Timmermans S , et al.
    PubMed:28784771
    MGI:J:244295
    Proc Natl Acad Sci U S A 114(34):9158-9163
    2004
    Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.
    Petkov PM , et al.
    PubMed:15081119
    MGI:J:89298
    Genomics 83(5):902-11
    1978
    Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.
    Cheers C , et al.
    PubMed:305895
    MGI:J:5965
    Infect Immun 19(3):755-62
    1971
    Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus.
    Heston WE , et al.
    PubMed:4322934
    MGI:J:24674
    Int J Cancer 7(1):141-8
    1970
    Genetic transmission of viruses that incite mammary tumor in mice.
    Bentvelzen P , et al.
    PubMed:4318784
    MGI:J:24803
    Proc Natl Acad Sci U S A 67(1):377-84
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    其他参考文献
    2014
    Deletion of IL-4Ralpha in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis.
    Orian JM , et al.
    PubMed:25427822
    MGI:J:220802
    Autoimmunity:1-14
    2013
    Spontaneous cardiac calcinosis in BALB/cByJ mice.
    Glass AM , et al.
    PubMed:23561935
    MGI:J:307779
    Comp Med 63(1):29-37
    2009
    Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen.
    Zhu W , et al.
    PubMed:19224206
    MGI:J:146790
    Immunogenetics 61(3):199-207
    2008
    Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain.
    Fairless AH , et al.
    PubMed:18662677
    MGI:J:138841
    Brain Res 1230:211-7
    2005
    Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides.
    Fichtner-Feigl S , et al.
    PubMed:16239967
    MGI:J:145688
    J Clin Invest 115(11):3057-71
    2005
    The allergy adjuvant effect of particles - genetic factors influence antibody and cytokine responses.
    Nygaard UC , et al.
    PubMed:15967044
    MGI:J:149209
    BMC Immunol 6:11
    2003
    Allergen-induced airway disease is mouse strain dependent.
    Whitehead GS , et al.
    PubMed:12626335
    MGI:J:84265
    Am J Physiol Lung Cell Mol Physiol 285(1):L32-42
    2002
    Retinal degeneration mutants in the mouse.
    Chang B , et al.
    PubMed:11853768
    MGI:J:75095
    Vision Res 42(4):517-25
    2002
    Home cage activity and behavioral performance in inbred and hybrid mice.
    Tang X , et al.
    PubMed:12429418
    MGI:J:80398
    Behav Brain Res 136(2):555-69
    2001
    Measuring normal and pathological anxiety-like behaviour in mice: a review.
    Belzung C , et al.
    PubMed:11682105
    MGI:J:72742
    Behav Brain Res 125(1-2):141-9
    2000
    Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.
    Ewart SL , et al.
    PubMed:11017920
    MGI:J:66641
    Am J Respir Cell Mol Biol 23(4):537-45
    1998
    Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.
    Roberts JE , et al.
    PubMed:9720874
    MGI:J:49726
    Mol Microbiol 29(2):581-91
    1992
    Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene.
    Okabe T , et al.
    PubMed:1730257
    MGI:J:2014
    Eur J Immunol 22(1):31-6
    1991
    Myoepitheliomas in inbred laboratory mice.
    Sundberg JP , et al.
    PubMed:1719689
    MGI:J:22767
    Vet Pathol 28(4):313-23
    1990
    Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.
    Paigen B , et al.
    PubMed:2317166
    MGI:J:22615
    Arteriosclerosis 10(2):316-23
    1989
    Deficiency of the corpus callosum: incomplete penetrance and substrain differentiation in BALB/c mice.
    Wahlsten D , et al.
    PubMed:2703941
    MGI:J:138843
    J Neurogenet 5(1):61-76
    1987
    Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains.
    Teuscher C , et al.
    PubMed:2446778
    MGI:J:149656
    Cell Immunol 110(2):294-304
    1986
    Differences in susceptibility of inbred mice to Bacillus anthracis.
    Welkos SL , et al.
    PubMed:3081444
    MGI:J:8197
    Infect Immun 51(3):795-800
    1985
    Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains.
    Roderick TH , et al.
    PubMed:3899524
    MGI:J:24307
    Curr Top Microbiol Immunol 122:9-18
    1984
    Hippocampal lamination defect = Hld.
    Nowakowski RS , et al.
    PubMed:
    MGI:J:13989
    Mouse News Lett 71:35
    1984
    The mode of inheritance of a defect in lamination in the hippocampus of BALB/c mice.
    Nowakowski RS , et al.
    PubMed:6536729
    MGI:J:7947
    J Neurogenet 1(3):249-58
    1982
    Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.
    Schlagel CJ , et al.
    PubMed:6980940
    MGI:J:6835
    J Immunol 129(4):1530-3
    1976
    Vaginal septa in mice: incidence, inheritance, and effect on reproductive, performance.
    Cunliffe-Beamer TL , et al.
    PubMed:1018474
    MGI:J:24296
    Lab Anim Sci 26(6 Pt 1):895-8
    1976
    Differences in tumor incidence in two substrains of Claude BALB/c (BALB/cfCd) mice, emphasizing renal, mammary, pancreatic, and synovial tumors.
    Sass B , et al.
    PubMed:185454
    MGI:J:24705
    Lab Anim Sci 26(5):736-41
    1972
    Genetic relationships between inbred strains of mice.
    Taylor BA , et al.
    PubMed:5031317
    MGI:J:24288
    J Hered 63(2):83-6
    1971
    Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors.
    Ebbesen P , et al.
    PubMed:4941118
    MGI:J:24297
    J Natl Cancer Inst 47(6):1241-5
    1952
    COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice
    International Nomenclature Committee , et al.
    PubMed:14945054
    MGI:J:166288
    Cancer Res 12(8):602-13
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