正常 C57BL/6J 小鼠的被毛为黑色,耳朵、眼睛和尾巴周围的毛发可呈现较浅的颜色(黄色/浅棕黄色);然而,老龄鼠可能会表现出以下这些自然衰老的特征:
- 灰白色被毛
- 毛发稀疏
老龄B6小鼠表现出灰白色背毛和毛发稀疏。
除了由于衰老而产生的正常特征(被毛变灰白或变稀疏)外,在我们 25 周龄之后的鼠群中还会出现某些特征,包括:
- 理毛:因小鼠的群居社交活动而引起的一种脱毛现象。因此,我们发送的老龄鼠可能会有脱毛或毛发/胡须稀疏的情况,这与衰老无关;但是我们的鼠群中不会出现炎症或皮炎等健康问题。
老龄B6小鼠出现理毛现象。
- 请勿将不同运输箱中的小鼠放到同一鼠笼中饲养。小鼠从离乳后立即进行分笼饲养,离乳时分在同一饲养笼中的小鼠可以生活在一起,如果之后将它们和不同鼠笼的小鼠饲养在一起,会出现相互攻击和打斗的现象。
- 将鼠笼放置在远离通道等易出现人流、噪音和振动的位置,并让笼子与墙壁之间保持一定的距离,以便尽可能将饲养环境中的噪音、振动和其他干扰降到最低。
- 护理和抓取小鼠时要轻柔、缓慢、安静,并尽可能减少护理和抓取次数。
- 增加筑巢料及富集物,如纸制隧道和玩具小屋,可以减少小鼠理毛行为。
老龄 B6 小鼠可出现口鼻部脱毛现象。
- 不支持按动物的重量下单,不可指定无掉须或脱毛的小鼠。
- 暂不支持特殊运输配置要求;小鼠将以在杰克森实验室设施中饲养时的分笼情况进行打包,每个饲养箱中小鼠数量最多为 10 只。
•临床生化
•身体成分分析
•器官重量
•脾脏的流式细胞仪分析显示,初始 T 细胞呈年龄依赖性降低,调节性 T 细胞和效应/效应记忆 T 细胞增加
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JAX 衰老研究中心利用生物学和基因组学方面的不同专业知识,研究与衰老相关的问题和疾病,有助于更好地理解寿命和健康寿命研究中的分子机制。查看来自 JAX 的老龄 B6 小鼠和其他小鼠模型的相关文献。
小鼠表型组数据库 (MPD) 是公开发布 Nathan Shock 中心生成的核心数据的主要数据库,并面向公众开放。MPD 公布了雄鼠和雌鼠的中位寿命和 Kaplan-Meier 生存曲线,以及所有品系的表型和基因型数据。
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